Histopathology of Experimental Eczema (Allergic Contact-Type Eczematous Dermatitis) in Man*

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HISTOPATHOLOGY OF EXPERIMENTAL ECZEMA (ALLERGIC CONTACT-TYPE ECZEMATOUS DERMATITIS) IN MAN* A STUDY BY THE TECHNICS OF SILVER IMPREGNATIONS OF Rio HORTEGA WITH SPECIAL REFERENCE TO THE EARLY MicRoscoPlclc LEsIoNs

Towards the end of the past century, IJnna and Besnier published their studies on histopathology of eczema (now often called "allergic eczematous contact-type dermatitis" a name coined by Sulzberger to distinguish this entity from atopic dermatitis and circumscribed lichen simplex). These descriptions are now classics and have been extensively quoted in most well-known textbooks of dermatology....

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Contact hypersensitivity and allergic contact dermatitis among school children and teenagers with eczema.

BACKGROUND Patch testing is an essential procedure in the investigation of eczema in children. OBJECTIVES To analyse the frequency of contact hypersensitivity and allergic contact dermatitis among Polish children with eczema. PATIENTS/METHODS During an allergy screening programme involving 9320 children aged 7 and 16 years, 12.6% reported symptoms of chronic/recurrent eczema. From this grou...

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Allergic Contact Dermatitis Physiology

Allergic Contact Dermatitis (ACD) involves the penetration of an allergen through the skin surface where it acts as a hapten by binding to epidermal proteins and eliciting, a delayed Type IV hypersensitivity reaction 48 to 120 hours after exposure. This immunologic response involves the activation of Th1 cells with the subsequent release of cytokines resulting in the classic inflammatory reaction.

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Allergic contact dermatitis

Allergic contact dermatitis is a T cell mediated, antigen-specific inflammatory reaction of the skin due to repeated epicutaneous exposure to antigens. Immunologically it is divided into 2 phases, induction and elicitation phase. During the first phase which is clinically silent, naïve T cells are activated and differentiate into antigen-specific memory T cells. During the elicitation phase, af...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 1949

ISSN: 0022-202X

DOI: 10.1038/jid.1949.78